Pharmacy online OTC

Which is better wellbutrin or cymbalta

Compare the effectiveness and side effects of Wellbutrin and Cymbalta to determine which medication may be better suited for your individual needs. Consider factors such as desired outcomes, personal medical history, and potential interactions with other medications.

Wellbutrin vs Cymbalta: Which is the Better Option?

When it comes to treating depression and anxiety disorders, there are a variety of medications available on the market. Two commonly prescribed options are Wellbutrin and Cymbalta. Both medications belong to the class of drugs known as antidepressants, but they work in different ways and have different side effects. This article will compare the two medications to help you understand which one may be the better option for you.

Wellbutrin: Also known by its generic name bupropion, Wellbutrin is a medication that primarily works by increasing the levels of certain chemicals in the brain, such as dopamine and norepinephrine. It is often prescribed to treat depression and seasonal affective disorder. Wellbutrin is also sometimes used as a smoking cessation aid. It’s important to note that Wellbutrin is not suitable for everyone and may have side effects such as insomnia, dry mouth, and increased heart rate.

Cymbalta: Cymbalta, or duloxetine, is another antidepressant medication that works by increasing the levels of serotonin and norepinephrine in the brain. In addition to treating depression, Cymbalta is also prescribed for generalized anxiety disorder, fibromyalgia, and chronic musculoskeletal pain. Common side effects of Cymbalta include nausea, drowsiness, and dizziness.

It’s important to consult with your doctor or healthcare provider before starting any medication, as they can evaluate your specific condition and medical history to determine which option may be best for you.

Overall, the choice between Wellbutrin and Cymbalta depends on various factors, such as the specific condition being treated, individual response to the medications, and potential side effects. Your doctor will be able to provide personalized advice and guidance to help you make an informed decision. Remember, it may take some trial and error to find the medication that works best for you, so be patient and open with your healthcare provider about any concerns or questions you may have.

Effectiveness and Mechanism of Action

Both Wellbutrin and Cymbalta are commonly prescribed antidepressants, but they differ in terms of their effectiveness and mechanism of action.


Wellbutrin, also known by its generic name bupropion, is classified as an atypical antidepressant. It works by inhibiting the reuptake of norepinephrine and dopamine, which are neurotransmitters involved in regulating mood and emotions. By increasing the levels of these neurotransmitters in the brain, Wellbutrin helps to alleviate symptoms of depression.

Studies have shown that Wellbutrin is effective in treating major depressive disorder, seasonal affective disorder, and certain types of anxiety disorders. It has also been prescribed off-label for smoking cessation.

Wellbutrin is generally well-tolerated, and it does not cause significant weight gain or sexual side effects, which are common with some other antidepressants. However, it may cause side effects such as dry mouth, headache, and insomnia.


Cymbalta, also known by its generic name duloxetine, is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine in the brain, which helps to regulate mood and pain perception.

Cymbalta is approved for the treatment of major depressive disorder, generalized anxiety disorder, fibromyalgia, and certain types of chronic pain, such as neuropathic pain and musculoskeletal pain. It has also been prescribed off-label for the treatment of other conditions, such as panic disorder and obsessive-compulsive disorder.

Studies have shown that Cymbalta is effective in reducing symptoms of depression and anxiety. It may also help to alleviate pain associated with certain medical conditions.

Common side effects of Cymbalta include nausea, dry mouth, dizziness, and fatigue. It may also cause sexual side effects and weight gain in some individuals.


Both Wellbutrin and Cymbalta have been shown to be effective in treating various mental health conditions. Wellbutrin primarily targets norepinephrine and dopamine, while Cymbalta primarily targets serotonin and norepinephrine. The choice between these medications depends on the specific symptoms and needs of the individual, as well as potential side effects and drug interactions. It is important to consult a healthcare professional to determine the most suitable option.

Side Effects and Tolerability

When considering the use of medication, it is important to weigh the potential side effects and how well the drug is tolerated by individuals. Both Wellbutrin and Cymbalta have their own set of side effects and tolerability profiles, which should be taken into account when making a decision.


Wellbutrin is generally well-tolerated, with most common side effects being mild and temporary. These may include dry mouth, headache, nausea, constipation, and insomnia. In some cases, individuals may experience increased anxiety, restlessness, or agitation. Rare but serious side effects may occur, such as seizures or allergic reactions. It is important to discuss any concerns or potential risks with a healthcare provider.

Wellbutrin is also known to have a lower risk of sexual side effects compared to some other antidepressant medications. This may be an important consideration for individuals who are concerned about the impact of medication on their sexual function.


Cymbalta, on the other hand, has a different side effect profile. Common side effects may include nausea, dry mouth, constipation, dizziness, and fatigue. Some individuals may also experience sexual side effects, such as decreased libido or difficulty achieving orgasm. In rare cases, Cymbalta may increase the risk of suicidal thoughts or behavior, particularly in children, adolescents, and young adults.

Additionally, Cymbalta has been associated with discontinuation syndrome, which can cause symptoms such as dizziness, nausea, headache, and irritability when stopping the medication abruptly. It is recommended to gradually reduce the dose under medical supervision to minimize the risk of these withdrawal symptoms.

Overall Comparison

When comparing the side effects and tolerability of Wellbutrin and Cymbalta, it is important to consider individual differences and preferences. Some individuals may find one medication more tolerable than the other, while others may experience different side effects. It is advisable to discuss these factors with a healthcare provider to determine the most suitable option for each individual.

Indications and Approved Uses

Both Wellbutrin and Cymbalta are FDA-approved medications used for different indications and have different approved uses.


  • Treatment of major depressive disorder (MDD)
  • Prevention of seasonal affective disorder (SAD)
  • Smoking cessation aid


  • Treatment of major depressive disorder (MDD)
  • Generalized anxiety disorder (GAD)
  • Fibromyalgia
  • Chronic musculoskeletal pain
  • Diabetic peripheral neuropathic pain
  • Chronic fatigue syndrome

It is important to note that while both medications are used for the treatment of depression, Cymbalta has a wider range of approved uses, including the treatment of anxiety disorders, fibromyalgia, and various types of chronic pain.

Dosage and Administration

Wellbutrin and Cymbalta have different recommended dosages and administration guidelines.


  • The typical starting dose of Wellbutrin is 150 mg per day, taken as a single dose in the morning.
  • For patients who do not experience adequate improvement in their symptoms after several weeks, the dosage may be increased to 300 mg per day, taken as 150 mg twice a day.
  • Wellbutrin should be swallowed whole and not crushed, chewed, or divided.
  • It is recommended to take Wellbutrin with food to help reduce the risk of gastrointestinal side effects.
  • The duration of treatment with Wellbutrin may vary depending on the individual’s response to the medication and the severity of their condition.


  • The recommended starting dose of Cymbalta is 30 mg per day, taken as a single dose.
  • For some patients, an initial dose of 60 mg per day may be more appropriate.
  • If needed, the dosage may be increased to a maximum of 120 mg per day, depending on the individual’s response and tolerability.
  • Cymbalta should be swallowed whole and not chewed or crushed.
  • It is recommended to take Cymbalta with or without food, as directed by the healthcare provider.
  • The duration of treatment with Cymbalta may vary depending on the individual’s response to the medication and the nature of their condition.

It is important to follow the prescribed dosage and administration instructions provided by the healthcare provider. Any changes to the dosage or treatment duration should be discussed with a healthcare professional.

Interactions with Other Medications

Both Wellbutrin and Cymbalta can interact with other medications, potentially leading to adverse effects or reduced effectiveness. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.

Wellbutrin may interact with monoamine oxidase inhibitors (MAOIs), causing a dangerous increase in blood pressure. It is essential to wait at least 14 days after discontinuing an MAOI before starting Wellbutrin. Additionally, Wellbutrin can lower the seizure threshold, so it should be used cautiously in individuals taking medications that may increase the risk of seizures.

Cymbalta can interact with several medications, including MAOIs, thioridazine, and linezolid. Combining Cymbalta with these drugs can lead to a life-threatening condition called serotonin syndrome, characterized by symptoms such as agitation, hallucinations, rapid heartbeat, fever, sweating, shivering, muscle stiffness, and tremors. It is crucial to allow a sufficient washout period before switching between Cymbalta and MAOIs.

Both medications can interact with drugs that affect liver enzymes, such as fluoxetine, paroxetine, and quinidine, potentially leading to increased blood levels of Wellbutrin or Cymbalta and an increased risk of side effects. Your healthcare provider may need to adjust the dosage of these medications accordingly.

It is important to note that this is not an exhaustive list of all possible interactions. Always consult with your healthcare provider or pharmacist to ensure the safe and effective use of these medications in combination with others.

Leave a Reply

Your email address will not be published. Required fields are marked *